Prescription Medications for the Treatment of Obesity

• Medications That Promote Weight Loss
• Single Drug Treatment
• Combined Drug Treatment
• Potential Benefits of Medication Treatment
• Potential Risks and Concerns When Considering Medication
• Commonly Asked Questions About Weight-Loss Medications
• What to Discuss with Your Doctor Before Choosing Weight-Loss Medication
• Appropriate Treatment Goals for Using Prescription Weight-Loss Medications

Medications That Promote Weight Loss

Most available weight-loss medications are "appetite-suppressant" medications. Appetite-suppressant medications promote weight loss by decreasing appetite or increasing the feeling of being full. These medications decrease appetite by increasing serotonin or catecholamine--two brain chemicals that affect mood and appetite.

In 1999, the drug orlistat was approved by the Food and Drug Administration (FDA) as an obesity treatment. Orlistat works by reducing the body's ability to absorb dietary fat by about one third.

Most currently available weight-loss medications are approved by the U.S. Food and Drug Administration (FDA) for short-term use, meaning a few weeks or months. Sibutramine and orlistat are the only weight-loss medications approved for longer-term use in significantly obese patients, although the safety and effectiveness have not been established for use beyond 1 year. (See table 1 for the generic and trade names of prescription weight-loss medications.) While the FDA regulates how a medication can be advertised or promoted by the manufacturer, these regulations do not restrict a doctor's ability to prescribe the medication for different conditions, in different doses, or for different lengths of time. The practice of prescribing medication for periods of time or for conditions not approved is known as "off-label" use. While such use often occurs in the treatment of many conditions, you should feel comfortable about asking your doctor if he or she is using a medication or combination of medications in a manner that is not approved by the FDA. The use of more than one weight-loss medication at a time (combined drug treatment) is an example of an off-label use. Using weight-loss medications other than sibutramine or orlistat for more than a short period of time (i.e., more than "a few weeks") is also considered off-label use.

Table 1

Prescription Weight-Loss Medications

Generic Name	Trade Name(s)
Dexfenfluramine	Redux (withdrawn)
Diethylpropion	Tenuate, Tenuate dospan
Fenfluramine	Pondimin (withdrawn)
Mazindol	Sanorex, Mazanor
Orlistat	Xenical
Phendimetrazine	Bontril, Plegine, Prelu-2, X-Trozine
Phentermine	Adipex-P, Fastin, Ionamin, Oby-trim
Sibutramine	Meridia

Single Drug Treatment

Some antidepressant medications have been studied as appetite-suppressant medications. While these medications are FDA approved for the treatment of depression, their use in weight loss is an "off-label" use. Studies of these medications generally have found that patients lost modest amounts of weight for up to 6 months. However, most studies have found that patients who lost weight while taking antidepressant medications tended to regain weight while they were still on the drug treatment.

NOTE: Amphetamines and closely related compounds are not recommended for use in the treatment of obesity due to their potential for abuse and dependence.

Combined Drug Treatment

Potential Benefits of Medication Treatment

Potential Risks and Concerns When Considering Medication

• Potential for Abuse or Dependence
  Currently, all prescription medications to treat obesity except orlistat are controlled substances, meaning doctors need to follow certain restrictions when prescribing many weight-loss medications. Although abuse and dependence are not common with non-amphetamine appetite-suppressant medications, doctors should be cautious when they prescribe these medications for patients with a history of alcohol or other drug abuse.

• Development of Tolerance
  Most studies of weight-loss medications show that a patient's weight tends to level off after 4 to 6 months while still on medication. While some patients and physicians may be concerned that this shows tolerance to the medications, the leveling off may mean that the medication has reached its limit of effectiveness. Based on the currently available studies, it is not clear if weight gain with continuing treatment is due to drug tolerance.

• Reluctance to View Obesity as a Chronic Disease
  Obesity often is viewed as the result of a lack of willpower, weakness, or a lifestyle "choice"--the choice to overeat and underexercise. The belief that persons choose to be obese adds to the hesitation of health professionals and patients to accept the use of long-term appetite-suppressant medication treatment to manage obesity. Obesity, however, is more appropriately considered a chronic disease than a lifestyle choice. Other chronic diseases, such as diabetes and high blood pressure, are managed by long-term drug treatment, even though these diseases also improve with changes in lifestyle, such as diet and exercise. Although this issue may concern physicians and patients, social views on obesity should not prevent patients from seeking medical treatment to prevent health risks that can cause serious illness and death. Appetite-suppressant medications are not "magic bullets" or a one-shot fix. They cannot take the place of improving one's diet and becoming more physically active. The major role of medications appears to be to help a person stay on a diet and exercise plan to lose weight and keep it off.

• Side Effects
  Because weight-loss medications are used to treat a condition that affects millions of people, many of whom are basically healthy, their potential for side effects is of great concern. Most side effects of these medications are mild and usually improve with continued treatment. Rarely, serious and even fatal outcomes have been reported. Two approved appetite-suppressant medications that affect serotonin release and reuptake have been withdrawn from the market (fenfluramine, dexfenfluramine). Medications that affect catecholamine levels (such as phentermine, diethylpropion, and mazindol) may cause symptoms of sleeplessness, nervousness, and euphoria (feeling of well-being).

  Sibutramine acts on both the serotonin and catecholamine systems, but unlike fenfluramine and dexfenfluramine, sibutramine does not cause release of serotonin from cells. The primary known side effects of concern with sibutramine are elevations in blood pressure and pulse, which are usually small but may be significant in some patients. People with poorly controlled high blood pressure, heart disease, irregular heart beat, or history of stroke should not take sibutramine, and all patients taking the medication should have their blood pressure monitored on a regular basis.

  Some side effects with orlistat include oily spotting, gas with discharge, urgent need to go to the bathroom, oily or fatty stools, an oily discharge, increased number of bowel movements, and inability to control bowel movements. These side effects are generally mild and temporary, but may be worsened by eating foods that are high in fat. Also, because orlistat reduces the absorption of some vitamins, patients should take a multivitamin at least 2 hours before or after taking orlistat.

  Primary pulmonary hypertension (PPH) is a rare but potentially fatal disorder that affects the blood vessels in the lungs and results in death within 4 years in 45 percent of its victims. It should be noted that the vast majority of cases of PPH have occurred in patients who were taking fenfluramine or dexfenfluramine, either alone or in combination. There have been only a few case reports of PPH in patients taking phentermine alone, although the possibility that phentermine alone may be associated with PPH cannot be ruled out. No cases of PPH have been reported with sibutramine, but because of the low incidence of this disease in the underlying population, it is not known whether or not sibutramine may cause this disease.

Commonly Asked Questions About Weight-Loss Medications

A: No. The use of weight-loss medications to treat obesity should be combined with physical activity and improved diet to lose and maintain weight successfully over the long term.

Q: Will I regain some weight after I stop taking weight-loss medications?

A: Probably. Most studies show that the majority of patients who stop taking weight-loss medications regain the weight they had lost. Maintaining healthy eating and physical activity habits will increase your likelihood of keeping weight off.

Q: How long will I need to take weight-loss medications to treat obesity?

A: The answer depends upon whether the medication helps you to lose and maintain weight and whether you have any side effects. Because obesity is a chronic disease, any treatment, whether drug or nondrug, may need to be continued for years, and perhaps a lifetime, to improve health and maintain a healthy weight. There is little information on how safe and effective weight-loss medications are for many years of use.

Q: What dosage of weight-loss medication would be right for me?

A: There is no one correct dose for weight loss medications. Your doctor will decide what works best for you based on his or her evaluation of your medical condition and response to treatment.

Q: I only need to lose 10 pounds. Are weight-loss medications appropriate for me?

A: Weight-loss medications may be appropriate for carefully selected patients who are at significant medical risk because of their obesity. They are not recommended for use by people who are only mildly overweight unless they have health problems that are made worse by their weight. These medications should not be used only to improve appearance.

What to Discuss with Your Doctor Before Choosing Weight-Loss Medication

How will I be evaluated to determine if I am an appropriate candidate for weight-loss medication?

Your physician will look at a number of factors to determine if you are a good candidate for prescription weight-loss medication. He or she will determine how overweight you are and where your body fat is distributed (see WIN's fact sheet Understanding Adult Obesity for further information). Your doctor may do the following:

• Take a careful medical history and perform a physical examination.

• Look at your personal weight history.

• Ask whether you have relatives with illnesses related to overweight, such as type 2 diabetes mellitus or heart disease.

• Discuss the methods you have used to lose weight in the past.

• Evaluate your risk for obesity-related health problems by measuring your blood pressure and doing blood tests.

What other medical conditions or medications might influence my decision to take a weight-loss medication?

It is important that you notify your physician if you have any of the following medical conditions:

• Pregnancy or breast-feeding

• History of drug or alcohol abuse

• History of an eating disorder

• History of depression or manic depressive disorder

• Use of monoamine oxidase (MAO) inhibitors or antidepressant medications

• Migraine headaches requiring medication

• Glaucoma

• Diabetes

• Heart disease or heart condition, such as an irregular heart beat

• High blood pressure

• Planning to have surgery that requires general anesthesia

Studies show that weight-loss medications work best when combined with a weight-management program that helps you improve your eating and physical activity habits. Ask your doctor any questions or concerns that you may have about good nutrition and physical activity.

Appropriate Treatment Goals for Using Prescription Weight-Loss Medications

Weight-loss medications should be used with a program of behavioral treatment and nutritional counseling designed to help you make long-term changes in your diet and physical activity. You should see your physician regularly so that he or she can monitor how you are responding to the medication, not only in terms of weight loss, but how it affects your overall health. Again, if you experience any serious symptoms, such as chest pains or shortness of breath, contact your doctor immediately.

Long-term use of prescription weight-loss medications may be helpful for carefully selected individuals, but little information is available on the safety and effectiveness of these medications when used for more than 2 years. By evaluating your risk of experiencing obesity-related health problems, you and your physician can make an informed choice as to whether medication can be a useful part of your weight-management program.

End note: This e-text is a modified version of a review article on the long-term use of appetite-suppressant medications to manage obesity appearing in a 1996 issue of the Journal of the American Medical Association. Both the review article and this fact sheet were developed with the advice of the National Task Force on Prevention and Treatment of Obesity, a working group of leading obesity and nutrition researchers from across the country. This e-text was revised in October 1997 in response to additional information reported regarding an association between valvular heart disease and certain weight-loss medications, in February 1998 in response to the approval of sibutramine, and in November 2000 in response to the approval of orlistat.